Tourists, who were evacuated from their hotel arrive at the University of Puerto Vallarta used as a shelter as Hurricane Patricia approaches the Pacific beach resort of Puerto Vallarta, Mexico October 23. 2015. [Photo/Agencies]

PUERTO VALLARTA- Hurricane Patricia, one of the most powerful storms on record, struck Mexico's Pacific coast on Friday, threatening to inflict catastrophic damage as emergency teams scrambled to evacuate thousands of people from homes and popular beach resorts.

Blowing winds of almost 165 miles per hour (266 km/h), the Category 5 hurricane had western Mexico on high alert, including Puerto Vallarta and smaller resorts along the coast.

"The truth is, I'm very, very nervous ... This is going to get very ugly and I'm sad I'm not with my family," said local hotel worker Fernando as he and other staff hunkered down in a room at the Hotel Estancia Dolphins in Punta Perula, locking the door and bracing for the storm's arrival in near darkness.

Pamela Garcia, a spokeswoman for Mexico's meteorological service, said Patricia hit near Punta Perula between Puerto Vallarta and the major cargo port of Manzanillo.

US weather experts said Patricia was the strongest storm yet registered in the Western Hemisphere, and the World Meteorogical Organization (WMO) compared it to Typhoon Haiyan, which killed thousands in the Philippines in 2013.

Mexican President Enrique Pena Nieto said it was hard to predict what damage would be done by the massive storm, which could be seen barreling into Mexico from outer space.

"But one thing we're certain of is that we're facing a hurricane of a scale we've never ever seen," he said in a radio interview.

Mexican and US officials said the unprecedented hurricane could wreak catastrophic damage.