Atletico Madrid manager Diego Simeone hugs Real Madrid manager Carlo Ancelotti before a Champions League Quarter Final First Leg match at Vicente Calderon in Madrid, April 14, 2015. [Photo/Agencies]

Madrid coach Carlo Ancelotti, who started with his favored attacking formation of Ronaldo on the left, Bale running up the right flank and Benzema as striker, substituted the France international with Francisco "Isco" Roman in the 76th.

Simeone then brought on Raul Garcia _ who has recovered from an arm injury _ for Antoine Griezmann, Atletico's top scorer with 21 goals.

Fernando Torres replaced Jorge "Koke" Resurrecion in the 81st and Atletico could have scored a late winner, only for Mandzukic's shot to be blocked by defender Raphael Varane.